Noscapine: from cough syrup to cancer

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Noscapine is a phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine exerts its antitussive effects through the activation of sigma opioid receptors. This agent appears to exert its antimitotic effect by binding to tubulin, resulting in a disruption of microtubule assembly dynamics and subsequently, the inhibition of mitosis and tumor cell death.

Here’s another mild compound that has been in use for quite some time and could be re-purposed as a cancer fighting drug, particularly in a cocktail approach. Its anti-mitotic properties would come in quite handy. As usual follow the links to find out what this compound offers.

A Safe Cough Suppressant with Newly Discovered Effects in Treating Cancer and Stroke

Microtubules, leukemia, and cough syrup

Study Shows That A Cough Medicine Ingredient Could Effectively Treat Prostate Cancer

Noscapine and Its Analogues as Anti-Cancer Agents

Antitumor Activity of Noscapine in Combination with Doxorubicin in Triple Negative Breast Cancer

Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway

Noscapine Induced Apoptosis via Downregulation of Survivin in Human Neuroblastoma Cells Having Wild Type or Null p53