Methyl Jasmonate – a natural anti-cancer compound with several modes of action

Methyl Jasmonate is a plant stress hormone that has significant anti-cancer properties. So how does MJ work? Let me count the ways. It arrests cell cycle, inhibiting cell growth and proliferation; causes cell death through the intrinsic/extrinsic pro-apoptotic, p53-independent apoptotic, and non-apoptotic (necrosis) pathways; detaches hexokinase from the voltage-dependent anion channel, dissociating glycolytic and mitochondrial functions, decreasing the mitochondrial membrane potential, favoring cytochrome c release and ATP depletion, activating pro-apoptotic and inactivating anti-apoptotic proteins; induces reactive oxygen species mediated responses; stimulates MAPK-stress signaling and redifferentiation in leukemia cells; inhibits overexpressed pro-inflammatory enzymes in cancer cells such as aldo-keto reductase 1 and 5-lipoxygenase; inhibits cell migration and shows antiangiogenic and anti-metastatic activities. The complete lack of toxicity to normal cells and the rapidity by which MJ causes damage to cancer cells, turns MJ into a promising anticancer agent that can be used alone or in combination with other agents.

Follow the links for the relevant research:

MJ modes of action

MJ modes of action

Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis

Jasmonates: Novel Anticancer Agents Acting Directly and Selectively on Human Cancer Cell Mitochondria

Advertisements

Betulinic Acid – an underrated natural compound with profound anti-cancer properties

Betulinic acid structure

Betulinic acid structure

Betulinic acid (3β, hydroxy-lup-20(29)-en-28-oic acid) is a pentacyclic triterpenoid of plant origin that is widely distributed in the plant kingdom throughout the world. It is known for its antiretroviral, antimalarial, anti-inflammatory, and anti-cancer properties and has been used in folk medicine for a variety of ailments.

 

Here are a few links to the relevant research:

Betulinic acid as a potent and complex antitumor phytochemical: a minireview (abstract only)

Betulinic acid-induced apoptosis in leukemia cells

Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion

Betulinic Acid for Cancer Treatment and Prevention

Anticancerous Efficacy of Betulinic acid: An Immunomodulatory Phytochemical

Potential Sources:

SkinActives

Z Natural Foods