Betulinic acid (3β, hydroxy-lup-20(29)-en-28-oic acid) is a pentacyclic triterpenoid of plant origin that is widely distributed in the plant kingdom throughout the world. It is known for its antiretroviral, antimalarial, anti-inflammatory, and anti-cancer properties and has been used in folk medicine for a variety of ailments.
Here are a few links to the relevant research:
Betulinic acid as a potent and complex antitumor phytochemical: a minireview (abstract only)
Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification (abstract only)
A Review on Preparation of Betulinic Acid and Its Biological Activities
Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments
Betulinic acid-induced apoptosis in leukemia cells
Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response
Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion
Betulinic Acid for Cancer Treatment and Prevention
Anticancerous Efficacy of Betulinic acid: An Immunomodulatory Phytochemical
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